Speaker
Description
Despite the dynamic development of tissue engineering, the regeneration of critical-sized bone defects is still challenging due to peri-implant infections, intense and chronic inflammations among others. Therefore, in order to obtain materials with modified and completely new biological properties, i.e. antibacterial or anti-inflammatory activity, polymer-ceramic composites were functionalized with polyphenolic compounds (PPh) extracted from Salvia officinalis L. The aim of this study was to assess the effect of incorporation of polyphenolic compounds into materials on the in vitro long-term hydrolytic degradation.
Using the solvent-casting method, polymer films (PCL, PLGA) and composites modified with bioactive glass (BG) were produced. The materials were modified with polyphenolic compounds (PPh) extracted from sage (1 and 4.5 wt.%). As the modifying phase, BG particles prepared by the sol-gel method (d50 - 2 μm), with the composition of (% mol) 40SiO2–54CaO–6P2O5 (30 wt.%) were used. During 6-month incubation in PBS, thermal (DSC) and mechanical properties, microstructure, surface chemical composition (SEM/EDX, FTIR-ATR), and mass changes were monitored. Furthermore the pH of media were measured during the test.
After 12 months of incubation in PBS, the surfaces of films were covered by calcium phosphate (CaP) layer. The presence of layer slowed down the degradation process, additionally modulated by the addition of PPh to PCL (PCL/PPh) and PCL-BG biocomposites (PCL-BG/PPh). It was manifested in mass increase during incubation and confirmed by SEM/EDX and FTIR-ATR analysis. The crystallinity of PCL in PCL/PPh and PCL-BG/PPh materials increased, correlating with the enhancement of mechanical properties. Nevertheless, a decrease in the pH of the incubation media indicates that the same addition of PPh enhances the degradation of the PLGA-based biomaterial (PLGA/PPh) and BG-modified PLGA films (PLGA-BG/PPh).
This work was supported by the National Science Centre, Poland Grant no. 2017/27/B/ST8/00195 (KCK).
| Speaker Country | Poland |
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