Speaker
Description
Nanocomposites biomaterials are largely developed in biomedical applications as imaging agents, as sensors, as smart drug delivery systems, etc…[1,2] However, while the inorganic nanoparticles (INPs) are classically embedded in the polymer matrix or coated with polymer, the direct and uniform anchoring of INPs at the surface of polymer nanoobjects is still a major challenge. This is especially true for electrospun polymer scaffolds where the incorporation of INPs results not only in beaded defects and a larger distribution in the diameter of the fibers, but also strongly impacts their mechanical and degradation properties, as well as the intrinsic properties of the INPs (eg. magnetism). In this contribution we will present an efficient strategy for the direct and uniform anchoring of INPs on functionalized-polylactide (PLA) nanofibers surface via a simple free ligand exchange procedure.[3] We will illustrate this strategy through two types of INPs: superparamagnetic iron oxide nanoparticles (SPIONs) to yield magneto-scaffolds and lanthanide-dopped hydroxyapatite nanoparticles (L-HA) to yield hybrid scaffolds with dual-modality imaging properties. For both type of biomaterials, full characterization will be provided with an emphasis on the morphology of the nanocomposites that present a well-defined quasi-monolayer of INPs with a complete and homogeneous coverage of the surface of PLA nanofibers by the INPs. The resulting higher outcome in terms of imaging and magnetic properties will be discussed in the frame of tissue engineering applications to demonstrate the high potential of these nanocomposites with well-defined interfaces.
[1]Amstad et al. Nanoscale 3, 2819 (2011)
[2]Chang et al. Plos One 10, e0140534 (2015)
[3] Awada et al. ACS Appl. Mater. Interfaces 11, 9519 (2019)
| Speaker Country | France |
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