Speaker
Description
Degradable elastomers and hydrogels are largely spread among biomedical applications owing to their potentials for use in medical devices, like surgical patchs, or as drug delivery systems, like subcutaneous therapeutic depot. [1]
However, standard linear elastomers prepolymers present some limitations: difficulty to modulate and reach the adequate properties due to their low molecular weight, limited functionality leading to low crosslinking efficiencies if no toxic photoinitiators are used.
To overcome these limitations, our team recently designed eight-armed polyether-polyester star block copolymers. These copolymers exhibited a significant interest, since it is possible to obtain either elastomer [2] or hydrogel [3] by adjusting the polyether-polyester ratio. Moreover, the chain ends can be functionalized either with (meth)acrylic groups to allow UV cross-linking or with bioadhesive groups to promote bioadhesion.
These copolymers are currently developed to produce a biodegradable self-rolled multi-layer patch that could be applied locally by colonoscopy without surgical intervention to treat alterations of colonic tissue.
In this communication, we will detail the synthesis of the polymers and the preparation of the elastomeric/hydrogel bi-layered construct. The mechanical properties of each layer and of the resulting patch will be discussed as a function of the selected elastomers and hydrogels layers. Evaluation of the patch ability to self-rolling, its loading capacities with drugs and its bioadhesive properties will be presented.
REFERENCES
[1] Rupnik et al., Macromol Biosci., 2016, 16, 1792-1802
[2] Gangolphe et al., Mater. Today Chemistry, 2019, 12, 209-221
[3] Buwalda et al., Polym. Degrad Stab., 2017, 137, 173-183
| Speaker Country | France |
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