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Additive manufacturing technologies offer the possibility to provide tailor-made implants for tissue regeneration approaches.[1] Depending on the techniques, different polymeric materials with highly specialized properties are needed.
One very promising technique is stereolithography, demanding photopolymers, polymers that are formed from liquid formulations by exposure with light.[2,3] Vinyl esters (VEs) have been established as biocompatible precursors for such 3D-printed implants.[4] VEs have about two orders of magnitude lower toxicity compared to (meth)acrylates, the benchmark materials in this field. Moreover, VEs have very favorable degradation products and are suitable for rigid (highly filled) bone-like materials [5] as well as soft tissue substitutes (hydrogels).[6] By molecular engineering of the polymer network architecture (e.g., by thiol-ene chemistry) and addition of toughness enhancers (e.g. end-modified polyesters), mechanical properties and degradation behavior can easily be adjusted [5], thereby providing an ideal material platform for different applications in tissue engineering and regenerative medicine.
[[1]] S. Baudis. Nachr. Chem. 2016, 64, 406.
[[2]] J. Stampfl, S. Baudis, et al. J. Micromech. Microeng 2008, 18, 125014.
[[3]] C. Hofstetter, S. Orman, et al. Add. Manu. 2018, 24, 166.
[[4]] B. Husár, C. Heller, et al. J. Polym. Sci. A 2011, 49, 4927.
[[5]] S. Orman, C Hofstetter, et al. J. Polym. Sci. A 2018, 57, 110.
[[6]] E. Zerobin, M. Markovic, et al. J. Polym. Sci. 2020, 58, 1288.
| Speaker Country | Austria |
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