Speaker
Description
Chronic bone infection is considered one of the most problematic biofilm-related infections with high morbidity and mortality rates, prolonged hospitalization and costly health care expenses [1]. Nanomedicine has entered into this scenario by bringing new approaches to develop new therapies to enhance the standards used today [2,3]. The scientific efforts are mainly focused on the design of new nanostructured materials with anti-infective properties for both prevention and treatment or the infections [4]. The characteristics of these materials must be tailored to achieve improved antimicrobial performance and good integration with the surrounding tissue [5,6]. Herein we will focus primarily on three areas: (i) new technological advances in the surface modification of biomaterials for the design of antimicrobial coatings; (ii) multifunctional scaffolds with antimicrobial properties and the ability to regenerate damaged tissue; and (iii) nanomaterials based on mesoporous silica nanoparticles with the capability to carry different families of antimicrobial agents to target the bacteria and/or biofilm, and release them in response to certain stimuli.
[1] C. R. Arciola, D. Campoccia, L. Montanaro, Nat. Rev. Microbiol. 2018, 16, 397.
[2] M. Gisbert-Garzarán, M. Manzano, M. Vallet-Regí, Pharmaceutics 2020, 12, 83.
[3] M.Vallet-Regí, D. Lozano, B. González, and I. Izquierdo-Barba. Adv. Healthcare Mater. 2020, 2000310
[4] R. Alvarez, S. Muñoz-Piña, M. U. González, I. Izquierdo-Barba, I. Fernández-Martínez, V. Rico, D. Arcos, A. García-Valenzuela, A. Palmero, M. Vallet-Regi, A. R. González-Elipe, J. M. García-Martín, Nanomaterials 2019, 9, 1217.
[5] M. Colilla, I. Izquierdo-Barba, M. Vallet-Regí, Medicines 2018, 5, 125
[6] M. Vallet-Regi, B. Gonzalez, I. Izquierdo-Barba, Int. J. Mol. Sci. 2019,
20, 3806
| Speaker Country | España |
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