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    EUROPEAN CONGRESS AND EXHIBITION ON ADVANCED MATERIALS AND PROCESSES - EUROMAT 2021

    13–17 Sept 2021 Virtual Conference
    Virtual
    Europe/Vienna timezone
    Thank you very much for your participation!

    Conference Secretary

    Hyperthermia heat dissipation mapping of magnetic chitosan films

    17 Sept 2021, 17:20
    20m
    Room 2

    Room 2
    Oral Presentation A8. Multi-purpose materials (electronic, magnetic, thermal, sensors/actuators, network materials)- incl. A7 & A10 A8_Multi-purpose materials (electronic, magnetic, thermal, sensors/actuators, network materials)

    Speaker

    Ms Ana Barra (Department of Materials and Ceramic Engineering and Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro)

    Description

    Magnetic hyperthermia uses magnetic nanoparticles (MNP) to heat tumor cells up to 40–45 °C, when exposed to an external alternating magnetic field (AMF) [1]. The major challenges of this promising therapy are the MNP aggregation and restriction of heat to the tumor area, which may cause burns and death of healthy cells [2]. MNP can be stabilized in composite materials to prevent aggregation and direct the heat to the tumor area. Herein, a flexible biocomposite film was developed containing MNP immobilized into a chitosan matrix. The effect of magnetite (1.5 or 2.25 w/v%) and glycerol (0.75 or 0.38 w/v%) concentrations and film thickness on the magnetic hyperthermia response was evaluated. The spatiotemporal hyperthermia heat dissipation mapping was performed using a Live Camera Alternating Magnetic Field (LC-AMF) setup. The highest heating was achieved with a 78.0 µm film containing 2.25 w/v% MNP and 0.75 w/v% glycerol. This biocomposite contains 37.95% Fe and shows a saturation magnetization of 41.33 emu/g. The film surface exposed to the AMF for 10 min reached 97 °C in dry conditions and 49 °C when submerged in cell culture medium. These results point the flexible magnetic biocomposites as promising materials for hyperthermia cancer therapy.

    Acknowledgements: This work was developed within the scope of projects CICECO (UIDB/50011/2020 & UIDP/50011/2020) and BIOFOODPACK (M-ERA-NET2/0021/2016). AB and PF thank FCT for grants SFRH/BD/148856/2019 and IF/300/2015, respectively. CN is grateful to national funds (OE), through FCT, I.P., for framework contract foreseen in numbers 4, 5 and 6 of the article 23, of the D-L 57/2016, of August 29, changed by Law 57/2017, of July 19. COST action 18132, Grant No. 46265 is acknowledged. J.K.W. and D.B. acknowledge support from SFI (16/IA/4584).MMC and LPF acknowledge FCT funding through UID/MULTI/04046/2019(BioISI).

    References
    [1] V.F. Cardoso et.al., Adv.Health.Mater. 2017,1700845,1-35.
    [2] Y-J Kim et.al., Adv.Funct.Mater. 2013,23,5753-5761.

    Speaker Country Portugal

    Authors

    Ms Ana Barra (Department of Materials and Ceramic Engineering and Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro) Dr Paula Ferreira (Department of Materials and Ceramic Engineering, CICECO – Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal) Prof. Dermot F. Brougham (School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland) Dr Cláudia Nunes (Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal) Prof. Liliana P. Ferreira (Biosystems and Integrative Sciences Institute (BioISI), Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal and Physics Department, University of Coimbra, 3004-516 Coimbra, Portugal) Prof. M. Margarida Cruz (Biosystems and Integrative Sciences Institute (BioISI), Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal) Dr Jacek K. Wychowaniec (School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland)

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